Wichtige Publikationen
Lehr- und Forschungsgebiet Gastroenterologie, Hepatologie und gastrointestinale und hepatobiliäre Onkologie
- Gautheron J, Vucur M, Reisinger F, Vargas Cardenas D, Roderburg C, Koppe C, Kreggenwinkel K, Schneider AT, Bartneck M, Neumann UP, Canbay A, Reeves HL, Luedde M, Tacke F, Trautwein C, Heikenwalder M, Luedde T. A positive feedback-loop between RIP3 and JNK controls Non-Alcoholic-Steatohepatitis. EMBO Mol Med. 2014 Jun 24. pii: e201403856. doi: 10.15252/emmm.201403856
- Vucur M, Reisinger F, Gautheron J, Janssen J, Roderburg C, Vargas Cardenas D, Kreggenwinkel K, Koppe C, Hakem R, Unger K, Weber A, Gassler N, Luedde M, Frey N, Neumann UP, Tacke F, Trautwein C, Heikenwalder M, Luedde T. RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling Caspase-8-and JNK-dependent compensatory cell proliferation. Cell Rep. 2013 Aug 29;4(4):776-90.
- Roderburg C, Urban GW, Bettermann K, Vucur M, Zimmermann H, Schmidt S, Janssen J, Koppe C, Knolle P, Castoldi M, Tacke F, Trautwein C, Luedde T. micro-RNA-profiling reveals a role for miR-29 in human and murine liver fibrosis. Hepatology 2011; 53(1):209-18.
- Bettermann K, Vucur M, Haybaeck J, Koppe C, Janssen J, Heymann F, Weber A, Weiskirchen R, Liedtke C, Gassler N, Müller M, de Vos R, Wolf MJ, Boege Y, Seleznik GM, Zeller N, Erny D, Fuchs T, Zoller S, Cairo S, Buendia MA, Prinz M, Akira S, Tacke F, Heikenwalder M, Trautwein C, Luedde T. TAK1 suppresses a NEMO-dependent, but NF-kappaB-independent pathway to liver cancer. Cancer Cell 2010; 17(5):481-96.
- Luedde T, Beraza N, Kotsikoris V, van Loo G, Nenci A, De Vos R, Roskams T, Trautwein C, and Pasparakis M. Deletion of NEMO/IKKgamma in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma. Cancer Cell 2007; 11: 119-132.