Wichtige Publikationen


Lehrstuhl für Physiologie

  1. Dürrnagel S, Kuhn A, Tsiairis CD, Williamson M, Kalbacher H, Grimmelikhuijzen CJ, Holstein TW, Gründer S. Three homologous subunits form a high-affinity peptide-gated ion channel in Hydra. J. Biol. Chem., 2010, 285, 11958-11965.
  2. Springauf S, Bresenitz P, Gründer S. The interaction between two extracellular linker regions controls sustained opening of acid-sensing ion channel 1. J. Biol. Chem., 2011, 286, 24374-24384.
  3. Wiemuth D und Gründer S. The pharmacological profile of brain liver intestine Na+ channel (BLINaC): inhibition by diarylamidines and activation by fenamates. Mol. Pharmacol., 2011, 80 (5), 911–919.
  4. Wiemuth D, Sahin H, Falkenburger BH, Lefèvre C, Wasmuth HE, Gründer S. BASIC - a bile acid-sensitive ion channel highly expressed in bile ducts. FASEB J., 2012, 26, 4122-4130.
  5. Bartoi T, Augustinowski K, Polleichtner G, Gründer S*, Ulbrich MH*. Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry. Proc. Natl. Acad. Sci. USA, 2014, 111(2), 8281-8286. and * contributed equally

Lehr- und Forschungsgebiet Physiologie, insbesondere Herz- und Kreislaufphysiologie

  1. Frank J.P. Kühn, Mathis Winking, Cornelia Kühn, Daniel C. Hoffmann and Andreas Lückhoff Surface expressions and channel function of TRPM8 are cooperatively controlled by transmembrane segments S3 and S4*. Pflügers Archive - European Journal of Physiology 2013 (in press)
  2. Winking M, Hoffmann DC , Kühn C, Hilgers RD , Lückhoff A, Kühn FJP. Importance of a Conserved Sequence Motif in Transmembrane Segment S3 for the Gating of Human TRPM8 and TRPM2. PLoS ONE 7(11): e49877. doi:10.1371
  3. Kühn FJ, Witschas K, Kühn C, Lückhoff A. Contribution of the S5-pore-S6 domain to the gating characteristics of the cation channels TRPM2 and TRPM8. J. Biol. Chem. 2010 Aug 27;285(35):26806-14

Lehr- und Forschungsgebiet Physiologie, insbesondere Neurophysiologie

  1. Eberhardt, M., J. Nakajima, A. B. Klinger, C. Neacsu, K. Hühne, A. O. O‘Reilly, A. M. Kist, A. K. Lampe, K. Fischer, J. Gibson, C. Nau, A. Winterpacht, A. Lampert. “Inherited pain: Sodium channel Nav1.7 A1632T mutation causes erythromelalgia due to a shift of fast inactivation.” Journal of Biological Chemistry; 2014 Jan 24, 289(4):1971-80.
  2. Sittl*, R., A. Lampert*, T. Huth, E. T. Schuy, A. S. Link, J. Fleckenstein, C. Alzheimer, P. Grafe and R. W. Carr. “Anti-cancer drug oxaliplatin induces acute cooling-aggravated neuropathy via Nav1.6-mediated resurgent and persistent current”. Proceedings of the National Academy of Sciences (PNAS) 2012, 109 (17): 6704-6709. (*shared first authorship)
  3. Klinger, A. B., M. Eberhardt, A. S. Link, B. Namer, E. T. Schuy, R. Sittl, T. Hoffmann, C. Alzheimer, T. Huth, R. W. Carr, A. Lampert. “Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons”. Molecular Pain, 2012, 8(1): 69. F1000Prime Recommended.
  4. O'Reilly, A. O., E. Eberhardt, C. Weidner, C. Alzheimer, B. A. Wallace and A. Lampert. “Bisphenol A binds to the local anesthetic receptor site to block the cardiac sodium channel”. PLoS One 2012, 7(7): e41667.
  5. Gurkiewicz, M., Korngreen, A., Waxman, S. G., Lampert, A., Kinetic Modeling of Nav1.7 Provides Insight Into Erythromelalgia-associated F1449V Mutation. Journal of Neurophysiolgy 2011, 105 (4): 1546-1557.