Wichtige Publikationen
Lehrstuhl für Physiologie
- Dürrnagel S, Kuhn A, Tsiairis CD, Williamson M, Kalbacher H, Grimmelikhuijzen CJ, Holstein TW, Gründer S. Three homologous subunits form a high-affinity peptide-gated ion channel in Hydra. J. Biol. Chem., 2010, 285, 11958-11965.
- Springauf S, Bresenitz P, Gründer S. The interaction between two extracellular linker regions controls sustained opening of acid-sensing ion channel 1. J. Biol. Chem., 2011, 286, 24374-24384.
- Wiemuth D und Gründer S. The pharmacological profile of brain liver intestine Na+ channel (BLINaC): inhibition by diarylamidines and activation by fenamates. Mol. Pharmacol., 2011, 80 (5), 911–919.
- Wiemuth D, Sahin H, Falkenburger BH, Lefèvre C, Wasmuth HE, Gründer S. BASIC - a bile acid-sensitive ion channel highly expressed in bile ducts. FASEB J., 2012, 26, 4122-4130.
- Bartoi T, Augustinowski K, Polleichtner G, Gründer S*, Ulbrich MH*. Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry. Proc. Natl. Acad. Sci. USA, 2014, 111(2), 8281-8286. and * contributed equally
Lehr- und Forschungsgebiet Physiologie, insbesondere Herz- und Kreislaufphysiologie
- Frank J.P. Kühn, Mathis Winking, Cornelia Kühn, Daniel C. Hoffmann and Andreas Lückhoff Surface expressions and channel function of TRPM8 are cooperatively controlled by transmembrane segments S3 and S4*. Pflügers Archive - European Journal of Physiology 2013 (in press)
- Winking M, Hoffmann DC , Kühn C, Hilgers RD , Lückhoff A, Kühn FJP. Importance of a Conserved Sequence Motif in Transmembrane Segment S3 for the Gating of Human TRPM8 and TRPM2. PLoS ONE 7(11): e49877. doi:10.1371
- Kühn FJ, Witschas K, Kühn C, Lückhoff A. Contribution of the S5-pore-S6 domain to the gating characteristics of the cation channels TRPM2 and TRPM8. J. Biol. Chem. 2010 Aug 27;285(35):26806-14
Lehr- und Forschungsgebiet Physiologie, insbesondere Neurophysiologie
- Eberhardt, M., J. Nakajima, A. B. Klinger, C. Neacsu, K. Hühne, A. O. O‘Reilly, A. M. Kist, A. K. Lampe, K. Fischer, J. Gibson, C. Nau, A. Winterpacht, A. Lampert. “Inherited pain: Sodium channel Nav1.7 A1632T mutation causes erythromelalgia due to a shift of fast inactivation.” Journal of Biological Chemistry; 2014 Jan 24, 289(4):1971-80.
- Sittl*, R., A. Lampert*, T. Huth, E. T. Schuy, A. S. Link, J. Fleckenstein, C. Alzheimer, P. Grafe and R. W. Carr. “Anti-cancer drug oxaliplatin induces acute cooling-aggravated neuropathy via Nav1.6-mediated resurgent and persistent current”. Proceedings of the National Academy of Sciences (PNAS) 2012, 109 (17): 6704-6709. (*shared first authorship)
- Klinger, A. B., M. Eberhardt, A. S. Link, B. Namer, E. T. Schuy, R. Sittl, T. Hoffmann, C. Alzheimer, T. Huth, R. W. Carr, A. Lampert. “Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons”. Molecular Pain, 2012, 8(1): 69. F1000Prime Recommended.
- O'Reilly, A. O., E. Eberhardt, C. Weidner, C. Alzheimer, B. A. Wallace and A. Lampert. “Bisphenol A binds to the local anesthetic receptor site to block the cardiac sodium channel”. PLoS One 2012, 7(7): e41667.
- Gurkiewicz, M., Korngreen, A., Waxman, S. G., Lampert, A., Kinetic Modeling of Nav1.7 Provides Insight Into Erythromelalgia-associated F1449V Mutation. Journal of Neurophysiolgy 2011, 105 (4): 1546-1557.